大便C艰难梭菌毒素

定义

上厕所 C固执的 毒素 test detects harmful substances produced by the bacterium Clostridioides固执的 (C固执的). This infection is a common cause of 腹泻 after antibiotic use.

选择的名字

Antibiotic associated colitis - 毒素; Colitis - 毒素; Pseudomembranous colitis - 毒素; Necrotizing colitis - 毒素; C固执的 - 毒素

How the Test is Performed

需要粪便样本. It is sent to a lab to be analyzed. There are several ways to detect C固执的 毒素 in the stool sample.

酶免疫测定法(环境影响评价) is most often used to detect substances produced by the bacteria. This test is faster than older tests, and simpler to perform. The results are ready in a few hours. However, it is slightly less sensitive than earlier methods. Several stool samples may be needed to get an accurate result.

A newer method is to use polymerase chain reaction (PCR) to detect the 毒素 genes. This is the most sensitive and specific test. Results are ready within 1 hour. Only one stool sample is needed.

How to Prepare for the Test

There are many ways to collect the samples.

• You can catch the stool on plastic wrap that is loosely placed over the toilet bowl and held in place by the toilet seat. Then you put the sample in a clean container.
• A test kit is available that supplies a special toilet tissue that you use to collect the sample. After collecting the sample, you put it in a container.

Do not mix urine, water, or toilet tissue with the sample.

For children wearing diapers:

• Line the diaper with plastic wrap.
• Position the plastic wrap so that it will prevent urine and stool from mixing. This will provide a better sample.

Why the Test is Performed

You may have this test if your health care provider thinks that 腹泻 is caused by the antibiotic medicines you have taken recently. Antibiotics change the balance of bacteria in the colon. This sometimes leads to too much growth of C固执的.

腹泻引起的 C固执的 after antibiotic use often occurs in people who are in the hospital. It also can occur in people who have not recently taken antibiotics. This can lead to a condition called pseudomembranous结肠炎.

正常的结果

No C固执的 检测到毒素.

Note: Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

Abnormal results mean that 毒素s produced by C固执的 are seen in the stool and are causing 腹泻.

风险

There are no risks associated with testing for C固执的 毒素.

注意事项

Several stool samples may be needed to detect the condition. This is particularly true if the older 环境影响评价 for 毒素 test is used.

参考文献

Burnham C-A D, Storch GA. 诊断微生物学. 在:Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21艾德. Philadelphia, PA: Elsevier; 2020:chap 195.

Gerding DN, Johnson S. 梭菌属的感染. In: Goldman L, Schafer AI, eds. Goldman-Cecil医学. 26日艾德. Philadelphia, PA: Elsevier; 2020:chap 280.

Gerding DN, Young VB, Donskey CJ. Clostridioides固执的 (formerly Clostridium difficle) infection. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9日艾德. Philadelphia, PA: Elsevier; 2020:chap 243.

Plourde AR, Beavis KG. Specimen collection and handling for diagnosis of infectious diseases. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24日艾德. Philadelphia, PA: Elsevier; 2022:chap 66.

Siddiqi HA, Rabinowitz S, Axiotis CA..Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24日艾德. Philadelphia, PA : Elsevier; 2022:chap 22.